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KMID : 0363220120500080730
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Korean Journal of Dermatology
2012 Volume.50 No. 8 p.730 ~ p.733
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Syphilid Showing a Histological Pattern of Granulomatous Inflammation
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Kim Eun-Kyung
Jung Kyung-Eun
Kim Hei-Sung
Lee Jun-Young
Kim Hyung-Ok
Park Young-Min
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Abstract
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Syphilid represents a great variety of clinical and histological patterns. As such, sometimes it is difficult to make a differential diagnosis from other skin diseases. The histopathologic findings of syphilid are different, according to the clinical types; macular, maculopapular, papulosquamous, and nodular type. Characteristically, there is a marked perivascular infiltration of plasma cells and lymphocytes with endothelial cell swelling in the dermis. Herein, we report a case of syphilid showing the unusual histological pattern of granulomatous inflammation. A 45-year-old male presented with erythematous papules on the scalp, trunk, arms and inguinal area for 2 months. The biopsy specimen showed a chronic granulomatous inflammation with multinucleated giant cells in the dermis. Serologic test for syphilis showed a strong positive, and the patient was diagnosed with secondary syphilis. He was treated with benzathine penicillin G and the skin lesions have successfully disappeared.
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KEYWORD
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Granulomatous inflammation, Syphilid
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